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Archive - Sep 26, 2019

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NCI Awards $1.86 Million Two-Year Contract to Aethlon Medical for Developing Device for Isolating Exosomes; Aethlon to Collaborate with U of Pittsburgh and Mass General on Project

On September 16, 2019, Aethlon Medical, Inc. (Nasdaq: AEMD), a therapeutic technology company focused on unmet needs in global health, announced that the National Cancer Institute (NCI) has awarded the Company an SBIR Phase 2 contract for Topic 359, a solicitation entitled "Technologies for Differential Isolation of Exosomes and Oncosomes." This solicitation prioritized the advancement of technologies for isolating exosomes from biofluids for applications in oncology research and clinical care. This contract will be funded with Federal funds from the NCI, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N91019C00042. Exosomes are nanoparticles that are abundantly released from cancer cells and carry the complement of a tumor's genetic and protein cargo, making them important targets for non-invasive liquid biopsies in cancer. Aethlon is actively developing assays in this area through its majority-owned subsidiary, Exosome Sciences, Inc. However, there remains a need for high-throughput and selective technologies which isolate exosomes from various bodily fluids that could be adopted in clinical workflows. A technology that resolves the bottleneck in methods for obtaining pure populations of exosomes is anticipated to have wide applicability to be paired with downstream genomic sequencing, proteomic profiling tests, and, potentially, for the development of therapeutic products.

Southern California’s Hoag Hospital to Study Unique Early Disease Markers (Exosomes) for Cancer Detection and Management in Those at High Genetic Risk of Cancer; Hospital Will Collaborate with Exosome Sciences and Aethlon Medical

On Septembr 24, 2019, Hoag Memorial Hospital Presbyterian, in Orange County, California, announced the start of a research study to identify and characterize potential early disease markers for cancer diagnostics, cancer progression, and treatment resistance. In partnership with Exosome Sciences (https://www.exosomesciences.com/, a subsidiary of Aethlon Medical, Inc. (Nasdaq: AEMD) (https://www.aethlonmedical.com/), scientists will study exosomes in cancer patients and individuals at high genetic risk for cancer (https://www.hoag.org/specialties-services/cancer/conditions/hereditary-c...). Exosomes are nanoparticles that are abundantly released from cancer cells and can provide a snapshot of a tumor’s genetic and protein cargo, making them important targets for non-invasive liquid biopsies in cancer. “Liquid biopsies have the potential to facilitate the early detection of cancer and the assessment of the efficacy of potential treatments in real time. This may prove to be a critical tool in our ongoing efforts to help patients with cancer,” said Michael Demeure, MD, Program Director of Precision Medicine at Hoag (https://www.hoag.org/specialties-services/cancer/treatments-services/pre...) and the principal investigator on the study at Hoag. “Hoag has an active Hereditary Cancer Program (https://www.hoag.org/specialties-services/cancer/conditions/hereditary-c...) that supports a number of individuals and families at high risk of developing cancer and is committed to achieving breakthroughs in the detection of cancer at its earliest possible and most treatable stage.” “Liquid biopsies are a rapidly developing field of non-invasive tests for patients with and at risk for cancer,” said Timothy Rodell, MD, CEO of Exosome Sciences and Aethlon Medical, Inc.