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Low-Cost Electronic Device May Reverse Early Stages of Pattern Baldness; Small, Wearable Device “Wakes Up” Dormant Hair Follicles, Restores Hair Growth; Device Developed by Engineers at UW-Madison

Reversing baldness could someday be as easy as wearing a hat, thanks to a noninvasive, low-cost hair-growth-stimulating technology developed by engineers at the University of Wisconsin (UW)–Madison. “I think this will be a very practical solution to hair regeneration,” says Xudong Wang, PhD, a Professor of Materials Science and Engineering at the University of Wisconsin (UW)–Madison. Dr. Wang and colleagues published a description of the technology in the journal ACS Nano on September 10, 2019. The article is titled “Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator. Based on devices that gather energy from a body’s day-to-day motion, the hair-growth technology stimulates the skin with gentle, low-frequency electric pulses, which coax dormant follicles to reactivate hair production. The devices don’t cause hair follicles to sprout anew in smooth skin. Instead, they reactivate hair-producing structures that have gone dormant. That means they could be used as an intervention for people in the early stages of pattern baldness, but they wouldn’t bestow cascading tresses to someone who has been completely bald for several years. Because the devices are powered by the movement of the wearer, they don’t require a bulky battery pack or complicated electronics. In fact, they’re so low-profile that they could be discreetly worn underneath the crown of an everyday baseball cap. Dr. Wang is a world expert in the design and creation of energy-harvesting devices. He has pioneered electric bandages that stimulate wound-healing and a weight-loss implant that uses gentle electricity to trick the stomach into feeling full. The hair-growth technology is based on a similar premise: small devices called nanogenerators passively gather energy from day-to-day movements and then transmit low-frequency pulses of electricity to the skin. That gentle electric stimulation causes dormant follicles to “wake up.”

“Electric stimulations can help many different body functions,” says Dr. Wang. “But, before our work, there was no really good solution for low-profile devices that provide gentle but effective stimulations.”

Because the electric pulses are incredibly gentle and don’t penetrate any deeper than the very outermost layers of the scalp, the devices don’t seem to cause any unpleasant side effects. That’s a marked advantage over other baldness treatments, like the medicine Propecia, which carries risks of sexual dysfunction, depression, and anxiety.

What’s more, in side-by-side tests on hairless mice, the devices stimulated hair growth just as effectively as two different compounds found in baldness medicines.

“It’s a self-activated system, very simple and easy to use,” says Dr. Wang. “The energy is very low, so it will cause minimal side effects.”

The researchers have patented the concept with the Wisconsin Alumni Research Foundation, and they hope to move forward with human testing soon.

Image

UW–Madison Materials Science and Engineering Professor Xudong Wang (left) and colleagues developed a device — unobtrusive enough to fit under a cap — that harnesses energy from the wearer and delivers gentle electric pulses to stimulate dormant hair follicles and regrow hair. (UW-Madison photo by Sam Million-Weaver).

[Press release] [ACS Nano abstract]

[CBS Boston article] [International Business Times article] [The Economic Times article] [Medical Daily article] [New Scientist article]