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New Treatment Significantly Improves Survival in Women Newly Diagnosed with Advanced Ovarian Cancer; International Study Shows Niraparib (PARP Inhibitor) Administration After Chemotherapy Reduces Risk of Relapse or Death by Nearly 40%

An international study demonstrates that, administering niraparib after conventional chemotherapy treatment in patients newly diagnosed with advanced ovarian cancer, improves their progression-free survival, and reduces their risk of relapse or death from this disease. The primary investigator of this study is Dr. Antonio González Martín, (Co-Director of Clinica Universidad de Navarra (Spain), and president of the Spanish Ovarian Cancer Research Group (GEICO). The New England Journal of Medicine published the research online on September 28, 2019. The NEJM article is titled “Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.” "We evaluated in this study the benefits of using niraparib after standard treatment of ovarian cancer based on chemotherapy after surgery. With this new therapeutic approach, we have observed a significant improvement in patient progression-free survival and a reduction of almost 40% of their risk of relapse,”says Dr. González Martín, first author of the article. Ovarian cancer is diagnosed every year in approximately 205,000 women worldwide, and is the fifth leading cause of cancer death in women in Europe. It is usually diagnosed between 45 and 75 years, although there is a significant number of patients from 30 years. It is the gynecological tumor that causes more deaths because most patients are diagnosed in an advanced stage of the disease, given the absence of early diagnostic techniques. In turn, up to 80% of those affected by advanced ovarian cancer relapse after treatment with surgery and chemotherapy. "This research arises from the need to look for new strategies and alternative therapies that increase the survival of patients with this disease," says an expert. The study was presented at the Annual Congress of the European Society for Medical Oncology (ESMO) held in Barcelona, Spain from September 27th to October 1st (https://www.esmo.org/Conferences/ESMO-Congress-2019). The research analyzed 733 newly diagnosed patients with advanced ovarian cancer (with serous histological type, or endometrium of high grade). The phase III clinical trial, conducted in 181 international centers, was coordinated by the Spanish Ovarian Cancer Research Group (GEICO), which is part of the European Network of Gynecological Oncological Trial Groups (ENGOT), associations of which Dr. González Martín is also president.

The work consisted of adding niraparib after the conventional first-line chemotherapy treatment for these patients after surgery. Niraparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor drug (PARP is an enzyme involved in DNA repair and cell death) that is used as maintenance therapy in women with ovarian cancer relapse, whether or not they have a mutated BRCA gene (associated with the risk of suffering from this disease). In turn, the effect of this treatment was also studied in patients with a type of defect in DNA repair called homologous recombination deficiency (HRD). In patients who did show this deficiency (half of the women in the study), the benefit of treatment was even more significant, achieving a 57% reduction in the risk of relapse or disease progression.

The safety profile of the drug was similar to that observed in other trials with niraparib. The study was funded by TESARO, a company belonging to the pharmaceutical company GlaxoSmithKline (GSK).

These findings, says Dr. Gonzalez, "suggest considering niraparib as a first option treatment for patients with advanced ovarian cancer after completing first-line chemotherapy."

CLINICA UNIVERSIDAD DE NAVARRA

Clinica Universidad de Navarra, with more than 2.850 full-time commitment professionals in both of its location --Pamplona and Madrid in Spain, is a research hospital and a model in personalized medicine in Spain. The hospital is renowned for its research and teaching labor, for its prestigious professionals, and its career in the diagnosis and treatment of complex pathologies.

Furthermore, it is a high-resolution hospital due to its diagnosis speed, that it is possible thanks to a multidisciplinary work and the acquisition of the latest technology. With all that, Clinica Universidad de Navarra is capable of providing 46 clinical and surgical specialties.

For the fifth consecutive year, the center has been the hospital with the best reputation in Spain (according to MRS ranking). More information at http://www.cun.es

[Press release] [NEJM abstract] [ESMO Congress 2019]